Bioactive Molecules From Fungi, Applications and Properties: a technological prospection

Authors

DOI:

https://doi.org/10.9771/cp.v17i3.59407

Keywords:

Fungi, Bioactive molecules, Bioprospecting.

Abstract

The objectives of this technological prospection were: (i) to map patent applications on bioactive molecules from fungi; (ii) to highlight the industrial opportunities for the application of fungi, yeasts and filamentous fungi; (iii) to analyze the methods and techniques described in the patents for obtaining bioactive molecules; and (iv) to highlight the biological properties of molecules produced by fungi. The technological prospection of bioactive molecules from fungi was conducted in the Orbit Intelligence database using two search strategies. The English words "bioactive" and "molecules" associated with the patent classifications "C12R-2001/654" (search 1) and "A61K-036/06" (search 2) were used. A total of 113 patent applications were identified, of which twenty-three documents were selected for analysis. It was found that bioactive substances from fungi have anti-tumor, anti-inflammatory, antiviral, biofumigant, antifungal and antioxidant properties and can be used in the cosmetic, pharmaceutical, food and agrochemical industries.

Downloads

Download data is not yet available.

Author Biographies

Jeferson de Menezes Souza, State University of Feira de Santana

Master in Ecology and Evolution from the State University of Feira de Santana in 2022.

Paulo José Lima Juiz, Federal University of Recôncavo da Bahia

PhD in Biotechnology from the State University of Feira de Santana in 2013.

Alice Ferreira-Silva, Federal University of Paraíba

PhD in Microbiology from the Federal University of Minas Gerais in 2014.

References

ADELEYE, T. M. et al. Ethanol production from cassava starch by protoplast fusants of Wickerhamomyces anomalus and Galactomyces candidum. Egyptian Journal of Basic and Applied Sciences, [s.l.], v. 7, n. 1, 2020.

AHMAD, R. et al. Ganoderma lucidum (Reishi) an edible mushroom/ a comprehensive and critical reviews of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties. Phytoterapy Research, [s.l.], v. 35, p. 6030, 6062, 2021.

ALBERTI, F. et al. Natural products from filamentous fungi and production by heterologous expression. Applied Microbiology and Biotechnology, [s.l.], v. 101, p. 493-500, 2017.

ALY, A. H. et al. Fifty years of drug discovery from fungi. Fugal Diversity, [s.l.], v. 50, p. 3-19, 2011.

AMORIM, M. et al. Antihypertensive effect of spent brewer yeast peptide. Process Biochemistry, [s.l.], v. 76, p. 213-218, 2019a.

AMORIM, M. et al. Valorization of spent brewer’s yeast: optimization of hydrolysis process towards the generation of stable ACE-inhibitory peptides. LWT – Food Science and. Tecnology, [s.l.], v. 111, p. 77-84, 2019b.

ARAÚJO, C. F. Moléculas bioativas – Limnoperna fortunei – Mexilhão Dourado. 2022. 102f. Dissertação (Mestrado em Engenharia de Materiais). Universidade Federal de Ouro Preto, Outro Preto, 2022.

BADALYAN, S. S.; BARKHUDARYAN, A.; RAPIOR, S. Medicinal macrofungi as cosmeceuticals: a review. International Journal of Medicinal Mushrooms, [s.l.], v. 24, n. 4, p. 1-13, 2022.

BALASUBRAMANIYAM, T. et al. A new perspective on metabolites and bioactive compounds from fungi. The American Journal of Chinese Medicine, [s.l.], v. 51, n. 7, 2023.

BARBOSA, J. R. et al. Polysaccharides of mushroom Pleurotus spp.: new extraction techniques, biological activities, and development on new technologies. Carbohydrate Polymers, [s.l.], v. 229, 2020.

BEZERRA, J. D. P. et al. The explosion of Brazilian endophytic fungal diversity: taxonomy and biotechnological potentials. In: SATYANARAYANA, T.; DESHMUKH, S.; DESHPANDE, M. (ed.). Advancing Frontiers in Mycology & Mycotechnology. Singapore: Springer, 2019. p. 405-433.

CAMARENA-POZOS, D. A. et al. Fungal volatiles emitted by members of the microbiome of desert plants are diverse and capable of promoting plant growth. Environmental Microbiology, [s.l.], v. 23, n. 4, 2021.

CARVALHO, C. R. et al. Diversity, Ecology, and bioprospecting of endophytic fungi in the Brazilian biomes of Rupestrian Grasslands, Caatinga, Pampa and Pantanal. In: ROSA, L. H. (ed.) Neotropical Endophytic Fungi: Diversity, Ecology, and Biotechnological Applications, 2021. p. 151-176.

CHATTERJEE, S. et al. Production of bioactive compounds with bactericidal and antioxidant potential by endophytic fungus Alternaria alternada AE1 isolated from Azadirachta indica A. Juss. PLoS ONE, [s.l.], v. 14, n. 4, 2019.

CORTELO, P. C. et al. Fungos ocultos dos biomas brasileiros. Ciência & Cultura, [s.l.], v. Biomas, 2023.

CRUZ, K. S. Hypoxylaceae (Ascomycota, Xylariales na Amazônia ocidental brasileira: taxonomia e bioprospecção de compostos bioativos. 2021. 139f. Tese (doutorado em Biodiversidade e Biotecnologia), Instituto Nacional de Pesquisas da Amazônia, Manaus, 2021.

DONG, C. et al. Identification of novel metabolic engineering targets for S-adenosyl-L-methionine production in Saccharomyces cerevisiae via genome-scale engineering. Metabolic Engineering, [s.l.], v. 66, p. 319-327, 2021.

EL-GENDY, M. M. A. et al. Production, and evaluation of antimycotic and antiheptatitis C virus potential of Fusant MERV6270 derived from mangrove endophytic fungi using novel substrates of agroindustrial wastes. Applied Biochemistry and Biotechnology, [s.l.], v. 174, 2014.

FERREIRA, V. V. R. et al. Patents, for what are they good? Academic chemistry researcher’s perceptions of patents and their importance. World Patent Information, [s.l.], v. 70, 2022.

GOMES-DA-SILVA, J. et al. Brazilian Flora 2020: Leveraging the power of collaborative scientific network. Taxon, [s.l.], v. 71, n. 1, p. 178-198, 2022.

HIRPARA, D. G. et al. Characterization and bioeffecacy of green nanosilver particles derived from fungicide-tolerant Tricho¬-fusant for efficient biocontrol of stem rot (Sclerotium rolfsii Sacc.) in groundnut (Arachis hypogaea L.). Journal of Microbiology, [s.l.], v. 59, 2021.

HUBERT, J. et al. Dereplication strategies in natural product research: how many tools and methodologies behind the same concept? Phytochemistry Reviews, [s.l.], v. 16, p. 55-95, 2017.

LIU, W. et al. Efficient production of S-adenosyl-L-methionine from DL-methionine in metabolic engineered Saccharomyces cerevisiae. Biotechnology and Bioengineering, [s.l.], v. 116, n. 12, p. 3.312-3.323, 2019.

LU, S. et al. Yeast engineering technologies and their applications to the food industry. Food Biotechnology, [s.l.], v. 32, n. 3, 2021.

MIRZAEI, M. et al. Bioactive peptides from yeast: a comparative review on production methods, bioactivity, structure-function relationship, and stability. Trends in Food Science & Technology, [s.l.], v. 118, p. 297-315, 2021.

MORAES, G. K. A. et al. Compostos orgânicos voláteis de fungos endofíticos e suas aplicações biotecnológicas. Revista Virtual de Químicas, [s.l.], v. 12, n. 6, 2020.

MOTA, E. M.; PEREIRA, J. R. D. Estudos sobre indicadores de produção científica versus produção tecnológica na Universidade Estadual de Maringá. Cadernos de Prospecção, Salvador, v. 12, n. 4, p. 795-809, dezembro, 2019.

MURALIDHAR, R., PANDA, T. Fungal protoplast fusion – a revisit. Bioprocess Engineering, [s.l.], v. 22, 2000.

NIEGO, A. G. T. et al. Macrofungi as a nutraceutical source: promising bioactive compounds and market value. Journal of Fungi, [s.l.], v. 7, n. 5, 2021.

NIEGO, A. G. T. et al. The contribution of fungi to the global economy. Fungal Diversity, [s.l.], v. 121, 2023.

NILSSON, R. H. et al. Mycobiome diversity: high-throughput sequencing and identification of fungi. Nature Reviews Microbiology, [s.l.], v. 17, 2019.

OLIVEIRA, A. S. et al. Spent brewer’s yeast (Saccharomyces cerevisiae) as a potential source of bioactive peptides: an overview. International Journal of Biological Macromolecules, [s.l.], v. 208, p. 1.116-1.126, 2022.

ORTEGA, H. S. et al. Patents on endophytic fungi for agriculture and bio and phytoremediation applications. Microorganisms, [s.l.], v. 8, n. 8, 2020.

ORTEGA, H. S. et al. Structurally uncommon secondary metabolites derived from endophytic fungi. Journal of Fungi, [s.l.], v. 7, n. 7, 2021.

PAPZAN, Z. et al. Strain improvement of Trichoderma spp. Through two-step protoplast fusion for cellulase production enhancement. Canadian Journal of Microbiology, [s.l.], v. 67, n. 5, 2021.

PHAM J. V. et al. A Review of the microbial production of bioactive natural products and biologics. Frontiers in Microbiology, [s.l.], v. 10, 2019.

PUTRA, I. P. et al. Review: current checklist of local names and utilization information of Indonesian Wild Mushrooms. Journal of Tropical Biodiversity and Biotechnology, [s.l.], v. 7, n. 3, 2022.

RAJA, H. A. et al. Fungal identification using molecular tools: a primer for the natural products research community. Journal of Natural Products, [s.l.], v. 80, n. 3, p. 756-770, 2017.

RAMAN, J. et al. Cultivation and nutritional value of prominent Pleurotus spp.: an overview. Microbiology, [s.l.], v. 49, n. 1, p. 1-14, 2020.

REIS, J. B. A. et al. Methods used for the study of endophytic fungi: a review on methodologies and challenges, and associated tips. Archives of Microbiology, [s.l.], v. 204, n. 675, 2022.

REIS, J. B. A. et al. How deep can the endophytic mycobiome go? A case study on six woody species from the Brazilian Cerrado. Journal of Fungi, [s.l.], v. 9, n. 5, 2023.

RIBEIRO, B. A. et al. Chemical Diversity of Secondary Metabolites produced by Brazilian endophytic fungi. Current Microbiology, [s.l.], v. 73, 2021.

SALAZAR-CEREZO, S. et al. Strategies for the development of industrial fungal producing strains. Journal of Fungi, [s.l.], v. 9, 2023.

SANCHEZ, S.; DEMAIN, A. L. Bioactive products from fungi. Food Bioactives, [s.l.], v. 11, 2017.

SEGNEANU, A. et al. Bioactive Molecules Profile from Natural Compounds. In: SEGNEANU, A. et al. Amino Acid – New Insights and Roles in Plant and Animal. London, UK: IntechOpen, 2017. p. 209-228.

SILVA, L. F. S. et al. Cacti as low-cost substrates to produced L-asparaginase by endophytic fungi. World Journal of Microbiology and Biotechnology, [s.l.], v. 38, 2022.

STROBEL, G. A. et al. The production of myco-diesel hydrocarbons and their derivatives by the endophytic fungus Gliocladium roseum (NRRL 50072). Microbiology, [s.l.], v. 154, n. 11, 2008.

TEKE, A. N. et al. Nutrient and mineral components of wild edible mushrooms from the Kilum-Ijim forest, Cameroon. African Journal of Food Science, [s.l.], v. 15, n. 4, p. 152-161, 2021.

TIAN, J. et al. Dibenzo-a-pyrones from the endophytic fungus Alternaria sp. Samif01: isolation, structure elucidation, and their antibacterial and antioxidant activities. Natural Product Research, [s.l.], v. 21, n. 4, 2017.

VAISHNAVI, K.; KUMAR, M. H. Endophytes as bioherbicides, biopesticides and bioinsecticides. In: CHANDRABHAN, A. R. (ed.). Research trends and innovations in plant pathology. Integrated Publication: India, 2021. p. 25-38.

WIPO – WORLD INTELLECTUAL PROPERTY ORGANAZATION. Resumo executivo índice global de inovação 2023. [2023]. Disponível: https://www.wipo.int/edocs/pubdocs/pt/wipo-pub-2000-2023-exec-pt-global-innovation-index-2023.pdf? Acesso em: 2 nov. 2023.

WU, S. et al. Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety, and clinical study. Food Science and Human Wellness, [s.l.], v. 13, n. 2, p. 568-596, 2024.

ZHOU, Y. Q. et al. Cultivable endophytic fungal community associated with the karst endemic plant Nervilia fordii and their antimicrobial activity. Frontiers in Microbiology, [s.l.], v. 13, p. 1-15, 2022.

Published

2024-07-01

How to Cite

Souza, J. de M., Juiz, P. J. L., & Ferreira-Silva, A. (2024). Bioactive Molecules From Fungi, Applications and Properties: a technological prospection. Cadernos De Prospecção, 17(3), 1007–1024. https://doi.org/10.9771/cp.v17i3.59407

Issue

Section

Prospecções Tecnológicas de Assuntos Específicos