Molecular Targets of Drugs in the Treatment of COVID-19

Authors

  • Irineu Ferreira da Silva Neto Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil https://orcid.org/0000-0002-7443-5651
  • Isadora Ellen Feitoza Ricardino Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil
  • Maria Nathalya Costa Souza Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil https://orcid.org/0000-0003-0545-5795
  • Rafael de Carvalho Mendes Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil

DOI:

https://doi.org/10.9771/cp.v13i5.38061

Keywords:

COVID-19, Mechanism of Action , Treatment.

Abstract

Having a COVID-19 pandemic, several researchers are looking for pharmacological strategies for the treatment of this disease. Objective: to expose the pharmacological results most found in the literature, frequently used in the treatment of COVID-19. A literature review was carried out, based on the electronic databases SciELO and PubMed, using the following descriptors: Fármacos “Drugs”, Tratamento “Treatment” e COVID-19. Selected publications between December 2019 and June 2020. Among the products most used in the treatment of COVID-19 are: Redemsivir, Favipiravir, Ribavirin, Arbidol, Hydroxychloroquine, Azithromycin, Interferon combined with beta-1b and association between Lopinavir / Ritonavir. The effects of these drugs are inhibited by: dependent RNA polymerase, virus fusion with target cell membrane, endosomal acidification, viral exocytosis and papain and 3C protease. The importance of controlled studies and changes according to each country is emphasized, since the physiological profile of each population differs from another.

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Author Biographies

Irineu Ferreira da Silva Neto, Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil

Student of the Pharmacy course at the Estácio de Juazeiro do Norte Faculty of Medicine

Isadora Ellen Feitoza Ricardino, Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil

Student of the Pharmacy course at the Estácio de Juazeiro do Norte Faculty of Medicine

Maria Nathalya Costa Souza, Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil

Student of the Pharmacy course at the Estácio de Juazeiro do Norte Faculty of Medicine

Rafael de Carvalho Mendes, Estácio de Juazeiro do Norte School of Medicine, Juazeiro do Norte, CE, Brazil

Professor of the Pharmacy course at the Estácio de Juazeiro do Norte Faculty of Medicine

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Published

2020-10-01

How to Cite

Silva Neto, I. F. da, Ricardino, I. E. F., Souza, M. N. C., & Mendes, R. de C. (2020). Molecular Targets of Drugs in the Treatment of COVID-19. Cadernos De Prospecção, 13(5), 1251. https://doi.org/10.9771/cp.v13i5.38061

Issue

Section

Coronavirus (SARS-COV-2) e COVID-19