Drugs for COVID-19: far beyond chloroquine (clinical trials for SARS-CoV-2 coronavirus)

Authors

DOI:

https://doi.org/10.9771/cp.v13i3.36815

Keywords:

Technological Maturity Levels (TRL), Viruses, Pandemics, Therapies, Technology Assessment.

Abstract

This work analyzes the drugs used for patients with COVID-19 which are undergoing clinical trials and that go well beyond chloroquine. The data were obtained from the World Health Organization's International Clinical Trials Registration Platform. Geodistribution shows concentration in China, and only 5% of transnational partnerships. Clinical tests are concentrated in intermediate phases II and III. The classes of drugs go far beyond antimalarials, which have become popularly known, also comprising antivirals, anti-inflammatories, antibiotics, anticoagulants, antibodies, antifibrotics, antitumor agents, calcium channel blockers, corticosteroids, immunomodulators, immunosuppressants, enzyme inhibitors, mucolytics, vasoconstrictors and vasodilators, vitamins and mineral salts. The most tested antivirals are Ritonavir, Remdesivir, Lopinavir, Favipiravir and Arbidol, as well as their associations. Several tests combine antimalarials, antivirals and immunomodulators, the most studied being Favipiravir and Lopinavir associated with Ritonavir, Methylprednisolone, Remdesivir, Tocilizumab, Chloroquine and Hydroxychloroquine.

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Author Biographies

Cristina M. Quintella, Federal University of Bahia, Salvador, BA, Brazil

  • ndereço para acessar este CV: http://lattes.cnpq.br/7897779819494573
  • ID Lattes: 7897779819494573

Lucilia Abreu Cabral e Silva, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

Address to access this CV: http://lattes.cnpq.br/0347804913790816 Graduated in Medicine (2014 - 2020) at the Federal University of Minas Gerais, Brazil. She was part of the Research Project on Neuropsychiatric Diseases, under the guidance of Professor Aline Miranda, at the Interdisciplinary Laboratory for Medical Research (LIIM), Faculty of Medicine, UFMG (2016 - 2017). He worked in the Extension Project Adopt your neighborhood in times of coronavirus, from the Faculty of Medicine of UFMG, which promotes the performance of students of Nursing and Medicine courses in the fight against the new coronavirus (2020).

Heitor da Mata Quintella, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

Address to access this CV: http://lattes.cnpq.br/6843746810740529 Graduated in Architecture and Urbanism from the Federal University of Bahia (2007-2011). Studying a degree in Medicine (2016 - Current) at the Federal University of Minas Gerais, Brazil

Gustavo Henrique Ramos Silva, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

Address to access this CV: http://lattes.cnpq.br/3352093665267223 Studying a degree in Medicine (2016 - Current) at the Federal University of Minas Gerais, Brazil. He has developed research in Cellular Neuroelectrophysiology, is former Marketing Director of the Study Group in Applied Didactics to Medicine Students – GEDAAM and current member of the Scientific Committee of the Society of Medical Academics of Minas Gerais – SAMMG.

Sávio Carlos Rodrigues da Silva, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

Address to access this CV: http://lattes.cnpq.br/9625804001105292 Studying a degree in Medicine (2016 - Current) at the Federal University of Minas Gerais, Brazil. She is part of the Research Group on Biology of the Lymphoid System and Regeneration, under the guidance of Professor Claudia Carvalho, at the Institute of Biological Sciences at UFMG (2017-current).

Sílvia Beatriz Beger Uchoa, Federal University of Alagoas, Maceio, AL, Brazil

Address to access this CV: http://lattes.cnpq.br/2912504494560823 Graduated in Civil Engineering from the Federal University of Mato Grosso (1984); Master's degree in Architecture and Planning from the School of Engineering of São Carlos, University of São Paulo (1989) and PhD in Chemistry and Biotechnology - Physical-Chemistry Concentration Area, from the Institute of Chemistry and Biotechnology of UFAL (2007). She is currently a retired professor at the Federal University of Alagoas, having been Vice-coordinator of the PROFNIT Professional Master's - Focal Point UFAL until August 2018. She works as a professor in the PROFNIT/UFAL master's degree. She was coordinator of the Center for Technological Innovation and Special Programs at PROPEP/UFAL, coordinating the Institutional Program for Initiation Scholarships in Technological Development and Innovation - PIBITI from 2010 to January 2016. She has experience in the areas of Civil Construction and Electrochemistry, with emphasis on Construction Materials and Components and Corrosion and Durability Tests, working mainly on the following topics: civil construction, construction materials, concrete properties, durability of reinforced concrete structures and building facade pathologies. She was vice-coordinator of FORTEC Regional NE from April 2010 to April 2012 and alternate on the Fiscal Council of ANPROTEC.

Pedro Miguel de Assis Lopes Tavares da Mata, Hospital Garcia de Orta, AV. Toasted da Silva, Pragal, Almada, Portugal

Graduation in Medicine with specialization in Internal Medicine and Geriatrics (1992) at Hospital das Clínicas in São Paulo, Brazil. Specialization in Homeopathy (1995) at the São Paulo Homeopathy Association. Master in Palliative Care (2013) at Escola Superior de Saúde Prof. Lopes Dias in Portugal

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Published

2020-05-29

How to Cite

Quintella, C. M., Silva, L. A. C. e, Quintella, H. da M., Silva, G. H. R., Silva, S. C. R. da, Uchoa, S. B. B., & Mata, P. M. de A. L. T. da. (2020). Drugs for COVID-19: far beyond chloroquine (clinical trials for SARS-CoV-2 coronavirus). Cadernos De Prospecção, 13(3), 599. https://doi.org/10.9771/cp.v13i3.36815

Issue

Vol. 13 No. 3 (2020)

Section

Coronavirus (SARS-COV-2) e COVID-19

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