Investigação Prospectiva do Novo Coronavírus e de Fármacos Antivirais com Potencial Atividade Terapêutica para o Tratamento de Pacientes Infectados pela COVID-19

Autores

DOI:

https://doi.org/10.9771/cp.v13i3.36384

Palavras-chave:

Coronavírus, COVID-19, Tratamento, Fármacos

Resumo

A pandemia de COVID-19, causada pelo novo Coronavírus, encontrado em dezembro de 2019 em Wuhan, na China, havia atingido 754.498 pessoas e causado a morte de 36.571 pessoas em todo o mundo até o dia 31 de março de 2020. O sistema de saúde mundial entrou em crise e um dos grandes gargalos é o tratamento dos pacientes infectados. Com o objetivo de fazer um mapeamento científico e tecnológico acerca desse novo vírus e de fármacos antivirais com potenciais atividades terapêuticas no tratamento da COVID-19, foram realizadas buscas e análises de artigos científicos e patentes em bases de dados nacionais e internacionais. Foram recuperadas 2.977 patentes (Orbit) e 14.056 artigos (Scopus) sobre Coronavírus e 296 artigos (Scopus) especificamente sobre o novo Coronavírus, predominantemente da China. Foram identificados mais de 20 fármacos antivirais em avaliação em diversas partes do mundo. O trabalho aponta para a potencialidade de uso de fármacos já existentes no tratamento à doença, a exemplo de Cloroquina, Hidroxicloroquina, Ritonavir, Lopinavir, Remdesivir e Ribavirin.

Downloads

Não há dados estatísticos.

Referências

AMIRIAN, E. Susan; LEVY, Julie K. Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses. One Health, [S.l.], p. 100128, 2020.

CAI, Qingxian et al. Experimental treatment with favipiravir for COVID-19: an open-label control study. Engineering, [S.l.], 2020.

CUI, J.; LI, F.; SHI, Z.L. Shi. Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol., [S.l.], n. 17, p. 181-192, 2019.

DERWENT. Base de dados on-line. [2020]. Disponível em: http://apps-webofknowledge.ez9.periodicos.capes.gov.br/DIIDW_GeneralSearch_input.do?product=DIIDW&SID=7Ar5bU9PQIZ4iN71VS3&search_mode=GeneralSearch. Acesso em: 30 mar. 2020.

DROSTEN, Christian et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. New England Journal of Medicine, [S.l.], v. 348, n. 20, p. 1.967-1.976, 2003.

ELFIKY, Abdo A. Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sciences, [S.l.], p. 117592, 2020.

ESPACENET. Base de dados on-line. [2020]. Disponível em: https://worldwide.espacenet.com/. Acesso em: 30 mar. 2020.

FAVALLI, Ennio Giulio et al. COVID-19 infection and rheumatoid arthritis: Faraway, so close! Autoimmunity Reviews, [S.l.], p. 102523, 2020.

FOSTER, S.; TYLER, V. E. Tyler's Honest Herbal, 4th ed. Binghamton, NY: Haworth Herbal Press, 1999, 442 p.

GILBERT, Marius et al. Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study. The Lancet, [S.l.], v. 395, n. 10.227, p. 871-877, 2020.

GUPTA, Ritesh; MISRA, Anoop. Contentious issues and evolving concepts in the clinical presentation and management of patients with COVID-19 infectionwith reference to use of therapeutic and other drugs used in Co-morbid diseases (Hypertension, diabetes etc.). Diabetes & Metabolic Syndrome: Clinical Research & Reviews, [S.l.], 2020.

HAN, Qingmei et al. Coronavirus 2019-nCoV: A brief perspective from the front line. Journal of Infection, [S.l.], v. 80, n. 4, p. 373-377, 2020.

INPI – INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL. Base de dados on-line. [2020]. Disponível em: https://gru.inpi.gov.br/pePI/jsp/patentes/PatenteSearchAvancado.jsp. Acesso em: 30 mar. 2020.

INPI – INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL. Classificação de patentes. 2020. Disponível em: http://www.inpi.gov.br/menu-servicos/patente/classificacao-de-patentes. Acesso em: 30 mar. 2020.

KHACHFE, Hussein H. et al. An epidemiological study on COVID-19: a rapidly spreading disease. Cureus, [S.l.], v. 12, n. 3, 2020.

KSIAZEK, Thomas G. et al. A novel coronavirus associated with severe acute respiratory syndrome. New England Journal of Medicine, [S.l.], v. 348, n. 20, p. 1.953-1.966, 2003.

LI, Heng et al. Coronavirus disease 2019 (COVID-19): current status and future perspective. International Journal of Antimicrobial Agents, [S.l.], p. 105951, 2020.

LI, Jin-Yan et al. The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future. Microbes and Infection, [S.l.], v. 22, n. 2, p. 80-85, 2020.

LI, Xiaowei et al. Molecular immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis, [S.l.], 2020.

PEERI, Noah C. et al. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? International Journal of Epidemiology, [S.l.], 2020.

QUESTEL ORBIT. Base de dados on-line. [2020]. Disponível em: https://www.orbit.com. Acesso em: 30 mar. 2020.

ROTHAN, Hussin A.; BYRAREDDY, Siddappa N. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity, [S.l.], p. 102433, 2020.

SCIENCE DIRECT. Base de dados on-line. [2020]. Disponível em: https://www.sciencedirect.com/. Acesso em: 30 mar. 2020.

SCIENTIFIC ELECTRONIC LIBRARY ONLINE (SciELO). Base de dados on-line. [2020]. Disponível em: http://www.scielo.org/php/index.php. Acesso em: 30 mar. 2020.

SCOPUS. Base de dados on-line. [2020]. Disponível em: https://www.scopus.com/home.uri. Acesso em: 30 mar. 2020.

SHEREEN, Muhammad Adnan et al. COVID-19 infection: origin, transmission, and characteristics of human coronaviruses. Journal of Advanced Research, [S.l.], 2020.

SIGMA-ALDRICH. Catálogo de produtos Químicos finos. [2020]. Disponível em: https://www.sigmaaldrich.com/catalog/product/aldrich/134910?lang=pt&region=BR. Acesso em: 31 mar. 2020.

SINGH, Awadhesh Kumar et al. Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, [S.l.], 2020.

TOURET, Franck; DE LAMBALLERIE, Xavier. Of chloroquine and COVID-19. Antiviral Research, [S.l.], p. 104762, 2020.

UNLUGENC, Hakki et al. Rapid fluid administration and the incidence of hypotension induced by spinal anesthesia and ephedrine requirement: the effect of crystalloid versus colloid coloading. Middle East J Anaesthesiol, [S.l.], v. 23, n. 3, p. 273-81, 2015.

WANG, Li-sheng et al. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. International Journal of Antimicrobial Agents, [S.l.], p. 105948, 2020.

WEB OF SICENCE. Base de dados on-line. [2020]. Disponível em: http://apps-webofknowledge.ez9.periodicos.capes.gov.br/WOS_GeneralSearch_input.do?product=WOS&search_mode=GeneralSearch&SID=7Ar5bU9PQIZ4iN71VS3&preferencesSaved=. Acesso em: 30 mar. 2020.

WEISS, Susan R.; LEIBOWITZ, Julian L. Coronavirus pathogenesis. In: WEISS, Susan R.; LEIBOWITZ, Julian L. Advances in Virus Research. [S.l.]: Academic Press, 2011. p. 85-164.

WHO – WORLD HEALTH ORGANIZATION. [2020]. Disponível em: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200331-sitrep-71-covid-19.pdf?sfvrsn=4360e92b_8. Acesso em: 31 mar. 2020.

WOO, Patrick Cy et al. Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. Journal of Virology, [S.l.], v. 86, n. 7, p. 3.995-4.008, 2012.

ZHAI, Pan et al. The epidemiology, diagnosis and treatment of COVID-19. International Journal of Antimicrobial Agents, [S.l.], p. 105955, 2020.

ZHANG, Wen et al. The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China. Clinical Immunology, [S.l.], p. 108393, 2020.

ZHU, Na et al. A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine, [S.l.], 2020.

Downloads

Publicado

2020-05-29

Como Citar

MORAIS, W. R. de S., Pereira Queiroz, N. M., Silva, J. S. da, Ribeiro, A. S., & Tonholo, J. (2020). Investigação Prospectiva do Novo Coronavírus e de Fármacos Antivirais com Potencial Atividade Terapêutica para o Tratamento de Pacientes Infectados pela COVID-19. Cadernos De Prospecção, 13(3), 619. https://doi.org/10.9771/cp.v13i3.36384

Edição

Seção

Coronavirus (SARS-COV-2) e COVID-19