Differences in the Distribution of Peripheral Blood Leukocyte and Lymphocyte Subsets in Pulmonary Tuberculosis Patients

Auteurs

  • Valdirene Leão Carneiro Universidade do Estado da Bahia
  • Rosalina Guedes Donato dos Santos Universidade Federal da Bahia
  • Geraldo Pedral Sampaio Universidade Federal da Bahia
  • Marilda Casela Universidade Federal da Bahia
  • Eduardo Martins Netto Universidade Federal da Bahia
  • Roberto José Meyer Nascimento Universidade Federal da Bahia
  • Songeli Menezes Freire Universidade Federal da Bahia

DOI :

https://doi.org/10.9771/cmbio.v13i2.12164

Mots-clés :

leucocytes, lymphocyte subsets, tuberculosis.

Résumé

Introduction: It has been suggested that individuals exposed to Mycobacterium tuberculosis can eliminate the infection through the innate immune response without the participation of the acquired immunity. However, T helper type 1 immune response is critical to control persistent infection. Objective: The purpose of this study was to evaluate the distribution of leukocyte and lymphocyte subsets in peripheral blood of individuals with pulmonary tuberculosis (TB) and positive Tuberculin Skin Test (TST). Methodology: In order to achieve that goal, we have collected blood sample from thirty-four treatment-naïve TB patients, fifty TST-positive and forty-one TST-negative individuals. Results: The evaluation has shown a significant reduction in the number of total lymphocytes, B cells, CD4+ and CD8+ T cells and percentage increase of NK cells, neutrophils and monocytes in TB patients, when compared to TSTpositive and TST-negative individuals. There was no statistical difference for leucocyte and lymphocyte subsets between TST-positive and TST-negative groups. Peripheral blood white cell counts change significantly at diagnosis. Conclusion: The quantification of these cells may support the diagnosis and monitoring of patients with pulmonary tuberculosis.

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Bibliographies de l'auteur

Valdirene Leão Carneiro, Universidade do Estado da Bahia

Professora do Departamento de Ciências da Vida, área: Imunologia

Rosalina Guedes Donato dos Santos, Universidade Federal da Bahia

Doutoranda do Programa de Pós-graduação em  Imunologia da UFBA, área Imunologia

Geraldo Pedral Sampaio, Universidade Federal da Bahia

Mestre pelo Programa de Pós-graduação em Biotecnologia da UFBA, área Biotecnologia

Marilda Casela, Universidade Federal da Bahia

Doutoranda do Programa de Pós-graduação em Processos Intteriativo de Orgão e Sistemas da UFBA, área Ciências da Saúde

Eduardo Martins Netto, Universidade Federal da Bahia

Doutor em Medicina e Médico infectologista do Hospital das Clínicas da UFBA

Roberto José Meyer Nascimento, Universidade Federal da Bahia

Professor Doutor do Departamento de Biointeração do Instituto de Ciências da Saúde da UFBA

 

Songeli Menezes Freire, Universidade Federal da Bahia

Professora do Departamento de Biointeração do Instituto de Ciências UFBA, área Imunologia

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Publiée

2014-01-05

Comment citer

Carneiro, V. L., Donato dos Santos, R. G., Sampaio, G. P., Casela, M., Netto, E. M., Nascimento, R. J. M., & Freire, S. M. (2014). Differences in the Distribution of Peripheral Blood Leukocyte and Lymphocyte Subsets in Pulmonary Tuberculosis Patients. Revista De Ciências Médicas E Biológicas, 13(2), 131–136. https://doi.org/10.9771/cmbio.v13i2.12164

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