Suscetibility association between HLA-DRB1 and DQB1 with localized aggressive periodontitis
DOI:
https://doi.org/10.9771/cmbio.v6i3.4387Keywords:
antígenos leucocitários humanos HLA, periodontite.Abstract
The aim of this study was compare the class II HLA profile of generalized (GAgP) and localized aggressive periodontitis (LAgP), case group with periodontally healthy patients (CG). The sample was composed of 34 patients with GAgP (mean age = 29.4, SD ± 4.6), 8 patients with LAgP (23.9, SD ± 5.8) and 46 CG patients (mean age= 42.8, SD ± 8.6). PCR-SSP was the method used to analysis the HLA genotype. Gene frequencies of the alleles HLA-DRB1* and HLA-DQB1* were calculated in both case and control groups. The results showed that alleles HLA-DRB1*08 and -DQB1*04 were found at a significantly (p < 0,05) higher level frequently associated with LAgP. IN conclusion, It might exist an association for susceptibility between Localized aggressive periodontitis and the HLA-DRB1*08 e HLA-DQB1*04.Downloads
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Published
2007-01-01
How to Cite
Terezan, M. L. F., Pontes, L., Porto, L. C., Marques, M. T., Fischer, R. G., & Figueredo, C. M. S. (2007). Suscetibility association between HLA-DRB1 and DQB1 with localized aggressive periodontitis. Journal of Medical and Biological Sciences, 6(3), 282–289. https://doi.org/10.9771/cmbio.v6i3.4387
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ORIGINAL ARTICLES
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