Recurrent Aphthous Ulcers and a possible association with stress

Abstract

Aphthous lesions are considered the most common oral mucosal disease known to humans beings, its regular presentation is round lesions, clearly defined, painful ulcers with shallow necrotic center, raised margins, and erythematous haloes. Up to now, no evidence of any single etiologic factor has been reported, however lots of studies consider stress a predisposing factor for its pathogenesis. Trying to reach a connection between both situations, this paper pains a literature review about the effects of stress in immune dysfunction, and its possible role in aphthous lesions pathogenesis.