Structural similarity between thyroid peroxidase [Homo sapiens] and SARS-CoV-2 spike glycoprotein

An autoimmune thyroiditis triggering mechanism in COVID-19 carriers?

Auteurs

  • Luis Jesuino de Oliveira Andrade Universidade Estadual de Santa Cruz https://orcid.org/0000-0002-7714-0330
  • Luisa Correia Matos de Oliveira
  • Alcina Maria Vinhaes Bittencourt Faculdade de Medicina - Universidade Federal da Bahia
  • Gabriela Correia Matos de Oliveira

DOI :

https://doi.org/10.9771/cmbio.v21i1.42332

Mots-clés :

Autoimmune thyroiditis. Thyroid peroxidase. SARS-CoV-2. Molecular mimicry

Résumé

Introduction: there are reports of autoimmune disease related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) such neurological syndromes and hematological syndromes, and more recently autoimmune thyroid dysfunctions have been described. These reports suggest that SARS-CoV-2 acts as a probable trigger for triggering the autoimmunity process. Aim: to evaluate structural similarity between thyroid peroxidase [Homo sapiens] (TPO) and SARS-CoV-2 spike glycoprotein (COVID-19), and to propose this similarity as a likely trigger for autoimmune thyroiditis. Methodology: using bioinformatics tools, we compare the amino acids (AA) sequences between protein structure of TPO and chain A COVID-19, chain B COVID-19, and chain C COVID-19, accessible in the National Center for Biotechnology Information database, by Basic Local Alignment Search Tool in order to locate the homologous regions between the sequences of AA. Results: the homology sequence between the TPO and COVID-19 ranged from 27.0 % (10 identical residues out of 37 AA in the sequence) to 56.0% (5 identical residues out of 9 AA in the sequence). The similar alignments demonstrated relatively high E values in function of short alignment. Conclusion: data suggest a possible pathological link between TPO and COVID-19. The structural similarity of AA sequences between TPO and COVID-19 may present a molecular mimicry suggesting the possibility of antigen crossover between TPO and COVID-19 that might represent an immunological basis for autoimmune thyroiditis associated with COVID-19.

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Publiée

2022-05-05

Comment citer

de Oliveira Andrade, L. J., Correia Matos de Oliveira, L. ., Vinhaes Bittencourt, A. M., & Correia Matos de Oliveira, G. . (2022). Structural similarity between thyroid peroxidase [Homo sapiens] and SARS-CoV-2 spike glycoprotein: An autoimmune thyroiditis triggering mechanism in COVID-19 carriers?. Revista De Ciências Médicas E Biológicas, 21(1), 94–97. https://doi.org/10.9771/cmbio.v21i1.42332

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