Antifungal activity of eukaryotic microalgae in dermatophytes

Autores/as

DOI:

https://doi.org/10.9771/cmbio.v22i4.52706

Palabras clave:

Microalgae, Chlorophycea, Diatom, Antifungal potential, Dermatophytosis

Resumen

Introduction: Microalgae are considered a promising source of biologically active secondary metabolites, with several biotechnological properties already recorded, including antifungal activity. Objective: Thus, the properties of ethanol extracts of microalgae Ankistrodesmus falcatus, Chaetoceros neogracilis, Desmodesmus brasiliensis, Dunaliella tertiolecta, Kirchneriella lunaris and Tetraselmis gracilis were investigated in vitro for antifungal activity against dermatophytes Nannizzia gypsea, Nannizzia nana, Trichophyton mentagrophytes and Trichophyton tonsurans. Methods: The extracts were evaluated using broth microdilution methodology, with a test interval of 0.0115 to 6 mg mL-1. The antifungal itraconazole was tested at concentrations 0.0313 to 16 μg mL-1. Results: All microalgae extracts showed antifungal activity, especially extracts from C. neogracilis, D. brasiliensis and K. lunaris that totally inhibited growth of all species of dermatophytes evaluated. The lowest MIC values recorded were for the extracts of D. brasiliensis and K. lunaris (MIC 0.188 mg mL-1), against T. tonsurans e N. nana. Conclusions: This was a pioneering work about the antifungal activity of these microalgae against dermatophytes. It is expected that, from this study, further research will be carried out in order to identify and isolate the active biomolecules responsible for the antifungal activity of these microalgae species.

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Biografía del autor/a

Vivian Marina Gomes Barbosa Lage, Federal University of Bahia

Master in Biotechnology, Federal University of Bahia, Salvador, BA.

Kathleen Ramos Deegan, Federal University of Bahia

Master in Biotechnology, Federal University of Bahia, Salvador, BA.

Gabriela Fontes Santos, Federal University of Bahia

Pharmacy Student, Federal University of Bahia, Salvador, BA.

Luzimar Gonzaga Fernandez, Federal University of Bahia

Doctor in Molecular Biology, Polytechnic University of Catalonia, Espanha.

Cristiane De Jesus Barbosa, Brazilian Agricultural Research Corporation - EMBRAPA

Doctor in Virology, Polytechnic University of Valencia, Spain.

Suzana Telles da Cunha Lima, Federal University of Bahia

Doctor in Plant Sciences, Campinas State University, Campinas, SP.

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Publicado

2023-12-22

Cómo citar

Lage, V. M. G. B., Ramos Deegan, K. ., Fontes Santos, G. ., Gonzaga Fernandez, L. ., Barbosa, C. D. J., & Telles da Cunha Lima, S. (2023). Antifungal activity of eukaryotic microalgae in dermatophytes. Revista De Ciências Médicas E Biológicas, 22(4), 615–622. https://doi.org/10.9771/cmbio.v22i4.52706