Thyroid stimulating hormone isn’t a sensitive indicator of iodine nutritional status in schoolchildren

Autores/as

  • Renata de Oliveira Campos UFBA
  • Joaquim Custódio Silva Júnior
  • Elton Estrela Ramos

DOI:

https://doi.org/10.9771/cmbio.v14i3.14990

Palabras clave:

Iodine Deficiency. Thyroid Functions Tests. Thyroid Stimulating Hormone.

Resumen

Introduction: iodine deficiency disorders (IDD) are most common cause of preventable brain damage, mental retardation and stunted growth in children worldwide. Several indicators are complementary to urinary iodine concentration (UIC) for assessing iodine nutritional status, as thyroid size, thyroglobulin (Tg) and thyroid stimulating hormone (TSH) concentrations in the blood. Objective: analyze TSH in filter paper blood values and correlate with UIC in schoolchildren from public school at state of Bahia, Brazil. Methodology: cross-sectional study was conducted in 880 schoolchildren aged 6-14 years, randomly selected, of public schools in five cities of four micro-regions of Bahia between October 2013 and September 2014. TSH was analyzed in filter-paper blood and UIC were measured by adapted Sandell-Kolthoff reaction. Results: 880 blood samples on filter-paper were analyzed for TSH. The reference range previously established is 0.72 to 6.0 μUI/mL. Results of this research TSH dosage ranged from 0.24 μIU/L to 7.71 μIU/L, with a mean of 1.01±0.55 μUI/L and median 0.89 μUI/L. Only one child presented TSH greater than 6.0 (7.71 μIU/L); however, results of urinary iodine were consistent with a more than adequate nutrition iodine (243.70μg/L). There’ no correlation between TSH and UIC (r= 0.115; p= 0.002). Conclusion:  in the present study, schoolchildren showed low values of TSH, but the mean UIC was indicative of adequate iodine nutrition.

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Biografía del autor/a

Renata de Oliveira Campos, UFBA

Doutoranda do Programa de Pós-graduação em Processos Interativos de Órgãos e Sistemas. Instituto de Ciência da Saúde, Universidade Federal da Bahia, Salvador, Brasil.

Joaquim Custódio Silva Júnior

Doutorando do Programa de Pós-graduação em Processos Interativos de Órgãos e Sistemas. Instituto de Ciência da Saúde, Universidade Federal da Bahia.

Elton Estrela Ramos

PhD, Professor Adjunto do Departamento de Biorregulação e do Programa de Pós-graduação Processos Interativos dos Órgãos e Sistemas, ICS,UFBA. Médico Endocrinologista

 

Publicado

2015-02-18

Cómo citar

Campos, R. de O., Silva Júnior, J. C., & Ramos, E. E. (2015). Thyroid stimulating hormone isn’t a sensitive indicator of iodine nutritional status in schoolchildren. Revista De Ciências Médicas E Biológicas, 14(3), 350–354. https://doi.org/10.9771/cmbio.v14i3.14990