Cytogenetic studies: Premature chromosome condensation (PCC) in peripheral blood lymphocytes cultures and skin warts lesions cultures induced by Papillomavirus spontaneous infection in bovines

Authors

  • Rachel Siqueira de Queiroz Simões Marins Universidade Federal Fluminense
  • Denise Monnerat Nogueira Universidade Federal Fluminense
  • Sílvia Regina Ferreira Gonçalves Pereira Universidade Federal Fluminense
  • Keila Mara Cassiano Universidade Federal Fluminense
  • Tábata Maues Universidade Federal Fluminense
  • Viviane Guimarães Dias Universidade Federal Fluminense
  • Lio Moreira Universidade Federal Fluminense
  • Eulógio Carlos Queiroz de Carvalho Universidade Federal Fluminense

DOI:

https://doi.org/10.9771/cmbio.v9i1.4770

Keywords:

Pappilomavirus (PV) PCC Bovine Infection

Abstract

Papillomavirus is a dermotropic oncogenic DNA virus which induces benign and malignant lesions described in a wide variety of hosts. Evidences suggest that the virus is species and tissue specific. However several reports have shown the development of lesions in phylogenetically close hosts. We analyzed a total of 30 blood and tumors samples from bovines affected cutaneous papillomatosis lesions. Our study reported premature chromosome condensation (PCC) in peripheral blood lymphocytes cultures and in skin warts cells cultures, and we detected epithelial cellular hyperproliferation confirmed by histological tissues processing. The morphology of the PCC reflects the cell cycle phase-specific exhibiting levels of the prematurely condensed chromatin. These results indicated a failed in the cellular control mechanism with disruption of mitotic checkpoints induced by virus spontaneous infection.

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Published

2010-10-27

How to Cite

Marins, R. S. de Q. S., Nogueira, D. M., Pereira, S. R. F. G., Cassiano, K. M., Maues, T., Dias, V. G., Moreira, L., & Carvalho, E. C. Q. de. (2010). Cytogenetic studies: Premature chromosome condensation (PCC) in peripheral blood lymphocytes cultures and skin warts lesions cultures induced by Papillomavirus spontaneous infection in bovines. Journal of Medical and Biological Sciences, 9(1), 3–9. https://doi.org/10.9771/cmbio.v9i1.4770

Issue

Vol. 9 No. 1 (2010): Journal of Medical and Biological Sciences

Section

ORIGINAL ARTICLES

License 

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