Prostaglandin A1 inhibits the replication of Sindbis virus in monkey kidney and mosquito cells
DOI:
https://doi.org/10.9771/cmbio.v7i2.4447Keywords:
Prostaglandin A1 - Sindbis virus - Vero cells - Aedes albopictus cells, Sindbis virus–PGA1, Vero cells - Sindbis virus - PGA1 - Proteins synthesis–Glycoproteins, Aedes albopictus cells - Sindbis virus - PGA1 - Proteins synthesis – Glycoproteins.Abstract
The present study reports the effect of prostaglandin A1 (PGA1) on the replication of Sindbis virus in monkey kidney and mosquito cells. In PGA1 treated cells we observed a severe reduction of virus yield. In both cells lines the highest nontoxic concentration of PGA1 (10 ìg/mL) decreased virus replication, dose dependently, by more than 90%. SDS-PAGE analysis of [35S] methionine labeled proteins showed that viral proteins (E1/E2 and C) were normally synthesized in PGA1 treated Vero cells, and induction of stress proteins (HSP70 and HSP90 ) was detected in uninfected and infected cells. In Vero cells the inhibition of virus replication was accompanied by a decrease in [3H] glucosamine incorporation into the virus glycoproteins.Downloads
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Published
2008-02-17
How to Cite
Gutarra, M. L. E., Burlandy, F. M., Meneses, M. D. F. de, Cortez, L. P., & Rebello, M. A. (2008). Prostaglandin A1 inhibits the replication of Sindbis virus in monkey kidney and mosquito cells. Journal of Medical and Biological Sciences, 7(2), 169–174. https://doi.org/10.9771/cmbio.v7i2.4447
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ORIGINAL ARTICLES
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