Cytochrome P450 enzymes and their correlation with the risk factors for the development of the oral cancer – state of the art
DOI:
https://doi.org/10.9771/cmbio.v6i2.4213Keywords:
Cytochromes P450 - Oral cavity- Carcinoma, Chemical carcinogenesis.Abstract
The development of oral cancer is associated to inherited risk factors and extrinsic risk factors, such as smoking, consumption of alcohol, diet and others. Xenobiotics (foreign substances) biotransformation is mainly catalyzed by enzymes cytochrome P450, present in the liver and in extra-hepatic localization, such as oral cavity and esophagus. and are highly activated in reactive composites that can interact with macromolecules, such as the DNA, leading to mutations, thus participating in carcinogenegis. The aim is to review the role of enzymes Cytochrome P450 in oral carcinogenesis and to discuss their correlation with risk factors involved in the development of oral cancer.Downloads
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Published
2007-01-01
How to Cite
Ferreira, D. de C., Meirelles Jr., V., Cunha, K. S. G., Janini, M. E. R., & Curvelo, J. A. da R. (2007). Cytochrome P450 enzymes and their correlation with the risk factors for the development of the oral cancer – state of the art. Journal of Medical and Biological Sciences, 6(2), 223–232. https://doi.org/10.9771/cmbio.v6i2.4213
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Review Articles
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