Evaluation of ibuprofen prescriptions into a Psychiatric Hospital: regarding safety, indication, and dose.

Authors

  • Carolina Rosario Dantas
  • Ricardo David Couto
  • Denis de Melo Soares Post-Graduation Program in Pharmacy, Faculty of Pharmacy, Federal University of Bahia http://orcid.org/0000-0003-1532-7332

DOI:

https://doi.org/10.9771/cmbio.v1i1.34579

Keywords:

Ibuprofen. Usage Studies. Safety. Anti-inflammatory. Medication. Hospital pharmacy.

Abstract

Introduction: non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are widely used throughout the world. In the psychiatric hospital, where this study was conducted, drugs such as selective serotonin reuptake inhibitors (SSRI) and lithium are widely used and may interact with ibuprofen (IBU). The literature also shows that ibuprofen may lead to changes in the central nervous system, which may trigger the imbalance of psychiatric disorders. Objective: to evaluate whether both the frequency of use and the prescriptions of ibuprofen are in agreement with the information contained in the literature regarding safety, indication, and dose. Methodology: retrospective observational cross-sectional study to evaluate the use of ibuprofen on patients from a psychiatric hospital. The prescriptions were evaluated for a 10-month period. Results: of the total number of prescriptions, 43 contained ibuprofen 600 mg. Note that in most cases, the drug was being prescribed according to the literature. However, in some cases there were divergences in the literature regarding: i) safety – information about the absence or presence of ulcers (1; 2.3%), gastrointestinal events (0; 0%) and absence of dyspepsia, abdominal pain and discomfort gastrointestinal (11; 25.5%) – ii) and the dose, in which in 19 cases (44%) it was higher than recommended by the literature. In addition, in 2 prescriptions (4.7%), the concomitant use of IBU and SSRI was observed and in 5 (11.6%) of IBU and lithium. Conclusion: the use of this drug often escaped safety and dosage criteria concerning scientific literature.

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Author Biographies

Carolina Rosario Dantas

 Graduated at Pharmacy from Universidade Federal da Bahia Master in
Pharmacy from Universidade Federal da Bahia.

Denis de Melo Soares, Post-Graduation Program in Pharmacy, Faculty of Pharmacy, Federal University of Bahia

Graduated at Pharmacy and Byochemistry from Universidade de São Paulo, master and doctorate degree at Medicine Faculty of Ribeirão Preto Pharmacology from Universidade de São Paulo. Associate Professor in Pharmacology at Pharmacy School of University of Bahia. Has experience in Medicine, acting on the following subjects: CNS, fever, mpges-1, lps and ibuprofen.

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Published

2020-06-17

How to Cite

Dantas, C. R., Couto, R. D., & Soares, D. de M. (2020). Evaluation of ibuprofen prescriptions into a Psychiatric Hospital: regarding safety, indication, and dose. Journal of Medical and Biological Sciences, 19(1), 58–65. https://doi.org/10.9771/cmbio.v1i1.34579