Annacardium occidentale Stem Bark Extract can Decrease the Efficacy of Antimicrobial Drugs

Autores

  • Marcus Vinícius Dias-Souza Universidade Vale do Rio Doce
  • João Luis Caldoncelli Universidade Vale do Rio Doce
  • Andrea Souza Monteiro Universidade Vale do Rio Doce

DOI:

https://doi.org/10.9771/cmbio.v12i2.7043

Palavras-chave:

Cashew, interference, antimicrobials.

Resumo

Background: Due to the growing use of phytotherapy clinical strategies for infectious diseases, healthcare providers and patients must know the risks of interactions between such preparations and synthetic drugs. Cashew extracts are widely used in Brazil for complementary treatments of infectious diseases, and often are combined to antimicrobial drugs. However, the possible consequences of such combinations are unknown. Objective: To assess the interference of the Cashew stem bark hydroethanolic extract (CSBE) on certain antimicrobials against clinical isolates of staphylococcal species. Methodology: Antimicrobial susceptibility test and interference assays were performed using gentamycin, ampicilin, ciprofloxacin, G penicillin, neomycin, rifampicin and vancomycin disks. Results: Here we show that the CSBE might reduce the therapeutic activity of some antimicrobial drugs in Staphylococcal species. We found in controlled in vitro assays that the antagonistic effect was seen in all antimicrobial drugs tested for most of the strains and statistically significant differences were found when compared to the control antimicrobials. Our results also indicate the presence of tannins, flavonoids and saponins in the CSBE. Conclusion: Such combinations are suggested to be not adequate for clinical treatments. Further researches are needed for a better understating of such interactions at the molecular level.

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Biografia do Autor

Marcus Vinícius Dias-Souza, Universidade Vale do Rio Doce

Mestre em Ciências Biológicas (Imunopatologia), pesquisador da Universidade Vale do Rio Doce.

João Luis Caldoncelli, Universidade Vale do Rio Doce

Mestrando em Ciências Biológicas (Imunopatologia), Universidade Vale do Rio Doce.

Andrea Souza Monteiro, Universidade Vale do Rio Doce

Doutorado em Ciências Biológicas (Microbiologia) pela Universidade Federal de Minas Gerais. Professora de adjunta e pesquisadora da Universidade do Vale do Rio Doce.

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Publicado

2013-11-08

Como Citar

Dias-Souza, M. V., Caldoncelli, J. L., & Monteiro, A. S. (2013). Annacardium occidentale Stem Bark Extract can Decrease the Efficacy of Antimicrobial Drugs. Revista De Ciências Médicas E Biológicas, 12(2), 163–167. https://doi.org/10.9771/cmbio.v12i2.7043